{"id":5143,"date":"2026-09-12T01:04:18","date_gmt":"2026-09-12T04:04:18","guid":{"rendered":"https:\/\/tucumandevelopers.com\/index.php\/2026\/09\/12\/how-a-researcher-uses-codex-and-chatgpt-to-search-for-new-antimicrobial-molecules\/"},"modified":"2026-09-12T01:04:18","modified_gmt":"2026-09-12T04:04:18","slug":"how-a-researcher-uses-codex-and-chatgpt-to-search-for-new-antimicrobial-molecules","status":"publish","type":"post","link":"https:\/\/tucumandevelopers.com\/index.php\/2026\/09\/12\/how-a-researcher-uses-codex-and-chatgpt-to-search-for-new-antimicrobial-molecules\/","title":{"rendered":"How a researcher uses Codex and ChatGPT to search for new antimicrobial molecules"},"content":{"rendered":"
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Only a fraction of a genome has a clearly understood function, and fewer still encode molecules that can fight infectious microbes. The challenge is to identify patterns that make a molecule functional, or biologically active, then determine which have the potential to combat infectious microbes.<\/span><\/p>\n

Scientists have long searched for antimicrobials in plants, animals, microbes, insects, water, and soil. They collect samples, isolate or predict candidate molecules, and test them in an iterative process that can take years.<\/span><\/p>\n

Digital genome and protein databases now let scientists search across the tree of life for new compounds, dramatically expanding the breadth of databases available for exploration. But that abundance of information comes with its own challenges: finding promising signals among an enormous number of possibilities.<\/span><\/p>\n

AI is particularly well suited to this needle-in-a-haystack task. It can scan huge datasets, identify patterns that might be difficult for researchers to spot, and prioritize a manageable set of candidates for experimental testing.<\/span><\/p>\n

But identifying a promising candidate doesn\u2019t necessarily mean that it will become an effective medicine.<\/span><\/p>\n

Scientists must first confirm that a candidate molecule kills the target microbe, determine the amount needed in order to be effective, and test how it affects human cells. Chemists may then optimize it to improve its effectiveness, safety, or stability.<\/span><\/p>\n

Further tests assess the dose at which the candidate becomes toxic, how readily microbes develop resistance to the molecule, and how the candidate moves through the body. Teams also determine a reliable way to manufacture the molecule. Candidates that clear these hurdles still face regulatory review and clinical trials before they can reach patients as approved antimicrobial drugs.<\/span><\/p>\n

For de la Fuente, this is why AI and laboratory biology must advance together. \u201cGround-truth experiments are essential to validate AI predictions,\u201d he said. \u201cThis will be critical in the life sciences in the years to come if we are to continue scratching the surface of our understanding of biology, which is the most complex thing out there.\u201d<\/span><\/p>\n

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A continually evolving collaborator<\/span><\/h2>\n<\/p>\n<\/div>\n

His lab explores the genomes of living and extinct organisms for candidate molecules. Searching those genomes, understanding how their encoded proteins form and function, and determining what those molecules do requires expertise spanning several fields.<\/span><\/p>\n

\u201cWe\u2019re a highly transdisciplinary group, so we have people from biology, from chemistry, from computer science, from engineering,\u201d said de la Fuente. Some lab members are strong programmers but know less about biology or chemistry and vice versa. Codex and ChatGPT help bridge those gaps, allowing biologists to build programs and programmers to tackle biological problems. In that sense, AI lowers barriers between scientific disciplines.<\/span><\/p>\n

It helps lab members review unfamiliar topics that they need for their cross-disciplinary work, clarify terminology, compare methods across fields, and organize ideas for drug discovery. Others use AI to download, organize, and pre-process large genome datasets. ChatGPT also lets lab members work in their native languages, lowering barriers to accelerate their workflows.<\/span><\/p>\n

De la Fuente uses ChatGPT as a brainstorming partner. He continues to develop ideas with colleagues, but he values AI\u2019s ability to help him shape a hypothesis. He also likes that he can access the world\u2019s information with a click of a button.<\/span><\/p>\n

\u201cOur ChatGPT workspace is receiving input from all these different people that think differently about the problems that we\u2019re trying to tackle,\u201d said de la Fuente. Lab members feed it their good and bad ideas, making it a kind of collaborative sounding board.<\/span><\/p>\n

But he cautions against relying on AI alone. \u201cObviously you have to always double-check for accuracy,\u201d de la Fuente said.<\/span><\/p>\n

Still, he appreciates AI\u2019s ability to help researchers explore the boundaries between scientific disciplines. \u201cThat\u2019s where the breakthroughs are waiting to be discovered. They\u2019re essentially at the edges between fields where very few people go.\u201d<\/span><\/p>\n

He sees this work as part of a much longer scientific tradition. \u201cWe have always relied on tools and machines to understand the world around us,\u201d said de la Fuente. \u201cThe telescope illuminated the cosmos, and the microscope revealed the world of the invisible.\u201d Machines now help researchers understand, predict, and engineer biology. \u201cThat is what our work is all about,\u201d he said.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Fuente: Art\u00edculo original<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Only a fraction of a genome has a clearly understood function, and fewer still encode molecules that can fight infectious microbes. The challenge is to identify patterns that make a molecule functional, or biologically active, then determine which have the potential to combat infectious microbes. Scientists have long searched for antimicrobials in plants, animals, microbes, […]<\/p>\n","protected":false},"author":1,"featured_media":5142,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"webixso_pending_account_ids":""},"categories":[43],"tags":[],"class_list":["post-5143","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-openai"],"jetpack_publicize_connections":[],"_links":{"self":[{"href":"https:\/\/tucumandevelopers.com\/index.php\/wp-json\/wp\/v2\/posts\/5143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tucumandevelopers.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tucumandevelopers.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tucumandevelopers.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tucumandevelopers.com\/index.php\/wp-json\/wp\/v2\/comments?post=5143"}],"version-history":[{"count":0,"href":"https:\/\/tucumandevelopers.com\/index.php\/wp-json\/wp\/v2\/posts\/5143\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tucumandevelopers.com\/index.php\/wp-json\/wp\/v2\/media\/5142"}],"wp:attachment":[{"href":"https:\/\/tucumandevelopers.com\/index.php\/wp-json\/wp\/v2\/media?parent=5143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tucumandevelopers.com\/index.php\/wp-json\/wp\/v2\/categories?post=5143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tucumandevelopers.com\/index.php\/wp-json\/wp\/v2\/tags?post=5143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}